Analysis and reflection on the transmission routes of SARS-COV-2 / 西安交通大学学报(医学版)

The novel coronavirus disease 2019 (COVID-19) outbreak occurred in December last year and spread quickly in the world, causing great harm to people. The rapid progression of this epidemic makes scholars in various fields conduct research on the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). So far, the wildly accepted routes are droplets and close contact. Controversially, some researchers believe that other routes include aerosol diffusion, fecal-oral transmission, contacting urine, conjunctival infection, and mother-to-infant transmission may also infect people. In this article, combining the newest research and reports, the authors systematically analyzed the theoretical possibility and real-life probability of the transmission routes of the virus in order to help with the research and clinical judgment of the spread of infectious diseases in the future.

Research on the effect and adverse drug reaction of Boulardii yeast combined triple and quadruple therapy on eradicating helicobacter pylori / 中国生化药物杂志

Objective To evaluate the effect and adverse drug reaction of Boulardii yeast combined with triple and quadruple therapy on eradication helicobacter pylori (H.pylori).Methods240 cases of peptic ulcer patients of H.pylori positive were selected in our hospital from January 2014 to December 2015, according to different treatment were divided into the triple threapy group(n=60), the triple therapy union group (n=60), the quadruple therapy group (n=60) and the quadruple therapy union group (n=60).The triple threapy group were given clarithromycin and amoxicillin and pantoraazole;on the basis of this, the triple therapy union group were given Boulardiiyeast.the quadruple therapy group were given clarithromycin and amoxicillin and pantoraazole and CBS capsule, on the basis of this, the quadruple therapy union group were given Boulardiiyeast.The four groups were treated continuously for 14 days.14C-UBT, H.pylori eradication rate and adverse drug reaction in the four groups were evaluated five weeks after treatment.ResultsCompared with the triple threapy group and the quadruple therapy group, H.pylori eradication rate in the triple therapy union group(91.2%) and the quadruple therapy union group(94.7%) were improved obviously, and the adverse drug reactions (31.6%、29.8%) decreased significantly, the cumulative recurrence rate of H.pylori were significantly decreased, and the differences were statistically significant (P< 0.05).ConclusionBoulardii yeast combined with triple and quadruple therapy can obviously increase the H.pylori eradication rate, reduce the incidence of adverse drug reactions and the risk of recurrence.The reasonable treatment plan should be selected according to the actual situation.